The Computational Modeling Core is focused on developing improved computational methods for use not only by TCNC investigators but also by the broader cancer community.
The Computational Modeling Core of the TCNC has three scientific foci: development of methods for extracting biological mechanism from large phosphoproteomic datasets; development of methods for using and analyzing dynamical systems models for biological networks; and development of methods for integrating proteomic and transcriptomic datasets. In addition, the Core is responsible for facilitating data-sharing among TCNC member labs.
Specific Aim 1 - Development of methods of integration of protein-protein interaction data and phosphopeptide databases
Specific Aim 2 - Enhancement of dynamic systems modeling capabilities
Specific Aim 3 - Enhancing integrated proteomic and transcriptomics network models