A reductionist's systems biology: opinion.

TitleA reductionist's systems biology: opinion.
Publication TypeJournal Article
Year of Publication2005
AuthorsSorger, PK
JournalCurr Opin Cell Biol
Date Published2005 Feb
KeywordsAnimals, Computational Biology, Computer Simulation, Models, Biological, Models, Theoretical, Molecular Biology, Software, Statistics as Topic, Systems Biology, Systems Theory

To tackle the complexity inherent in understanding large networks of interacting biomolecules, systems biology emphasizes cybernetic and systems theoretical approaches. The resulting focus on organization independent of physical manifestation threatens to throw away all that has been learned from molecular studies and ignores the reality that biologists are drawn together more by a shared interest in mechanism and structure than anything else. The field of reaction engineering suggests a reductionist approach to systems biology that fits easily within existing molecular paradigms but that can nonetheless be integrated into expansive physiological perspectives through the use of multi-scale modeling.

Alternate JournalCurr. Opin. Cell Biol.
PubMed ID15661513
Grant ListCA11296 / CA / NCI NIH HHS / United States
GM68762 / GM / NIGMS NIH HHS / United States