Title | A reductionist's systems biology: opinion. |
Publication Type | Journal Article |
Year of Publication | 2005 |
Authors | Sorger, PK |
Journal | Curr Opin Cell Biol |
Volume | 17 |
Issue | 1 |
Pagination | 9-11 |
Date Published | 2005 Feb |
ISSN | 0955-0674 |
Keywords | Animals, Computational Biology, Computer Simulation, Models, Biological, Models, Theoretical, Molecular Biology, Software, Statistics as Topic, Systems Biology, Systems Theory |
Abstract | To tackle the complexity inherent in understanding large networks of interacting biomolecules, systems biology emphasizes cybernetic and systems theoretical approaches. The resulting focus on organization independent of physical manifestation threatens to throw away all that has been learned from molecular studies and ignores the reality that biologists are drawn together more by a shared interest in mechanism and structure than anything else. The field of reaction engineering suggests a reductionist approach to systems biology that fits easily within existing molecular paradigms but that can nonetheless be integrated into expansive physiological perspectives through the use of multi-scale modeling. |
DOI | 10.1016/j.ceb.2004.12.012 |
Alternate Journal | Curr. Opin. Cell Biol. |
PubMed ID | 15661513 |
Grant List | CA11296 / CA / NCI NIH HHS / United States GM68762 / GM / NIGMS NIH HHS / United States |