Phosphoproteomics: unraveling the signaling web.

TitlePhosphoproteomics: unraveling the signaling web.
Publication TypeJournal Article
Year of Publication2008
AuthorsHuang, PH, White, FM
JournalMol Cell
Date Published2008 Sep 26
KeywordsAnimals, DNA Damage, Humans, Phosphoproteins, Proteomics, Receptor Protein-Tyrosine Kinases, Signal Transduction

In recent years, phosphoproteomic technologies have increased our understanding of cellular signaling networks. Here, we frame recent phosphoproteomics-based advances in the context of the DNA damage response and ErbB receptor family signaling and offer a perspective on how the molecular insights arising from the integration of such proteomic approaches might be used for clinical applications.

Alternate JournalMol. Cell
PubMed ID18922462
PubMed Central IDPMC2754874
Grant ListR01 CA096504-07 / CA / NCI NIH HHS / United States
R01 CA096504-09 / CA / NCI NIH HHS / United States
R01 CA118705-01A2 / CA / NCI NIH HHS / United States
U54 CA112967-05 / CA / NCI NIH HHS / United States