Phospho-Ser/Thr-binding domains: navigating the cell cycle and DNA damage response.

TitlePhospho-Ser/Thr-binding domains: navigating the cell cycle and DNA damage response.
Publication TypeJournal Article
Year of Publication2013
AuthorsReinhardt, HC, Yaffe, MB
JournalNat Rev Mol Cell Biol
Volume14
Issue9
Pagination563-80
Date Published2013 Sep
ISSN1471-0080
KeywordsCell Cycle, DNA Damage, DNA Repair, Humans, Models, Molecular, Phosphoserine, Phosphothreonine, Protein Binding, Protein Structure, Tertiary, Proteins
Abstract

Coordinated progression through the cell cycle is a complex challenge for eukaryotic cells. Following genotoxic stress, diverse molecular signals must be integrated to establish checkpoints specific for each cell cycle stage, allowing time for various types of DNA repair. Phospho-Ser/Thr-binding domains have emerged as crucial regulators of cell cycle progression and DNA damage signalling. Such domains include 14-3-3 proteins, WW domains, Polo-box domains (in PLK1), WD40 repeats (including those in the E3 ligase SCF(╬▓TrCP)), BRCT domains (including those in BRCA1) and FHA domains (such as in CHK2 and MDC1). Progress has been made in our understanding of the motif (or motifs) that these phospho-Ser/Thr-binding domains connect with on their targets and how these interactions influence the cell cycle and DNA damage response.

DOI10.1038/nrm3640
Alternate JournalNat. Rev. Mol. Cell Biol.
PubMed ID23969844
Grant ListCA112967 / CA / NCI NIH HHS / United States
ES015339 / ES / NIEHS NIH HHS / United States
ES020466 / ES / NIEHS NIH HHS / United States
GM68762 / GM / NIGMS NIH HHS / United States
U54 CA112967 / CA / NCI NIH HHS / United States