Building robust transcriptomes with master splicing factors.

TitleBuilding robust transcriptomes with master splicing factors.
Publication TypeJournal Article
Year of Publication2014
AuthorsJangi, M, Sharp, PA
JournalCell
Volume159
Issue3
Pagination487-98
Date Published2014 Oct 23
ISSN1097-4172
KeywordsAlternative Splicing, Animals, Feedback, Gene Expression Regulation, Developmental, Homeostasis, Humans, Organ Specificity, RNA Splicing, RNA-Binding Proteins, Transcription Factors, Transcriptome
Abstract

Coherent splicing networks arise from many discrete splicing decisions regulated in unison. Here, we examine the properties of robust, context-specific splicing networks. We propose that a subset of key splicing regulators, or "master splicing factors," respond to environmental cues to establish and maintain tissue transcriptomes during development.
DOI10.1016/j.cell.2014.09.054
Alternate JournalCell
PubMed ID25417102
PubMed Central IDPMC4243530
Grant ListP30 CA014051 / CA / NCI NIH HHS / United States
P30-CA14051 / CA / NCI NIH HHS / United States
R01 CA133404 / CA / NCI NIH HHS / United States
R01 GM034277 / GM / NIGMS NIH HHS / United States
R01-CA133404 / CA / NCI NIH HHS / United States
R01-GM34277 / GM / NIGMS NIH HHS / United States
U54-CA112967 / CA / NCI NIH HHS / United States