Title | Genetic strategy to prevent influenza virus infections in animals. |
Publication Type | Journal Article |
Year of Publication | 2008 |
Authors | Chen, J, Chen, SC, Stern, P, Scott, BB, Lois, C |
Journal | J Infect Dis |
Volume | 197 Suppl 1 |
Pagination | S25-8 |
Date Published | 2008 Feb 15 |
ISSN | 0022-1899 |
Keywords | Animals, Animals, Genetically Modified, Birds, Chickens, Ducks, Humans, Immunity, Innate, Influenza in Birds, Poultry, Poultry Diseases, RNA Interference |
Abstract | The natural reservoirs of influenza viruses are aquatic birds. After adaptation, avian viruses can acquire the ability to infect humans and cause severe disease. Because domestic poultry serves as a key link between the natural reservoir of influenza viruses and epidemics and pandemics in human populations, an effective measure to control influenza would be to eliminate or reduce influenza virus infection in domestic poultry. The development and distribution of influenza-resistant poultry represents a proactive strategy for controlling the origin of influenza epidemics and pandemics in both poultry and human populations. Recent developments in RNA interference and transgenesis in birds should facilitate the development of influenza-resistant poultry. |
DOI | 10.1086/524987 |
Alternate Journal | J. Infect. Dis. |
PubMed ID | 18269324 |
PubMed Central ID | PMC2694447 |
Grant List | AI 56267 / AI / NIAID NIH HHS / United States CA 112967 / CA / NCI NIH HHS / United States CA 119349 / CA / NCI NIH HHS / United States R01 AI056267-01 / AI / NIAID NIH HHS / United States R01 AI056267-02 / AI / NIAID NIH HHS / United States R01 AI056267-03 / AI / NIAID NIH HHS / United States R01 AI056267-04 / AI / NIAID NIH HHS / United States U54 CA112967-019003 / CA / NCI NIH HHS / United States U54 CA112967-029003 / CA / NCI NIH HHS / United States U54 CA112967-039003 / CA / NCI NIH HHS / United States U54 CA112967-049003 / CA / NCI NIH HHS / United States U54 CA112967-059003 / CA / NCI NIH HHS / United States |