Title | Building robust transcriptomes with master splicing factors. |
Publication Type | Journal Article |
Year of Publication | 2014 |
Authors | Jangi, M, Sharp, PA |
Journal | Cell |
Volume | 159 |
Issue | 3 |
Pagination | 487-98 |
Date Published | 2014 Oct 23 |
ISSN | 1097-4172 |
Keywords | Alternative Splicing, Animals, Feedback, Gene Expression Regulation, Developmental, Homeostasis, Humans, Organ Specificity, RNA Splicing, RNA-Binding Proteins, Transcription Factors, Transcriptome |
Abstract | Coherent splicing networks arise from many discrete splicing decisions regulated in unison. Here, we examine the properties of robust, context-specific splicing networks. We propose that a subset of key splicing regulators, or "master splicing factors," respond to environmental cues to establish and maintain tissue transcriptomes during development. |
DOI | 10.1016/j.cell.2014.09.054 |
Alternate Journal | Cell |
PubMed ID | 25417102 |
PubMed Central ID | PMC4243530 |
Grant List | P30 CA014051 / CA / NCI NIH HHS / United States P30-CA14051 / CA / NCI NIH HHS / United States R01 CA133404 / CA / NCI NIH HHS / United States R01 GM034277 / GM / NIGMS NIH HHS / United States R01-CA133404 / CA / NCI NIH HHS / United States R01-GM34277 / GM / NIGMS NIH HHS / United States U54-CA112967 / CA / NCI NIH HHS / United States |