Adaptive protein and phosphoprotein networks which promote therapeutic sensitivity or acquired resistance.

TitleAdaptive protein and phosphoprotein networks which promote therapeutic sensitivity or acquired resistance.
Publication TypeJournal Article
Year of Publication2014
AuthorsHaley, J, White, FM
JournalBiochem Soc Trans
Volume42
Issue4
Pagination758-64
Date Published2014 Aug
ISSN1470-8752
KeywordsDrug Resistance, Neoplasm, Humans, Mass Spectrometry, Neoplasms, Phosphoproteins, Proteomics, Signal Transduction
Abstract

Despite the emergence of dozens of oncogenic targets and corresponding molecularly targeted therapies, in most cases tumours continue to progress or recur due to therapeutic resistance. In the present review, we highlight the ability of MS-based phosphoproteomics to quantify oncogenic signalling networks driving tumour growth and invasion, as well as those networks enabling tumour cell survival in the presence of chemotherapeutics. Quantitative protein phosphorylation profiling will facilitate the design and development of optimal therapeutic strategies targeting the initial tumour while simultaneously blocking the predominant resistance mechanisms.

DOI10.1042/BST20140038
Alternate JournalBiochem. Soc. Trans.
PubMed ID25109954
Grant ListU24 CA159988 / CA / NCI NIH HHS / United States
U24CA159988 / CA / NCI NIH HHS / United States
U54 CA112967 / CA / NCI NIH HHS / United States
U54CA112967 / CA / NCI NIH HHS / United States